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Rragatm1.1Dmsa
Targeted Allele Detail
Summary
Symbol: Rragatm1.1Dmsa
Name: Ras-related GTP binding A; targeted mutation 1.1, David Sabatini
MGI ID: MGI:5499905
Synonyms: RagAGTP, RagAQ66L
Gene: Rraga  Location: Chr4:86493910-86495522 bp, + strand  Genetic Position: Chr4, 40.69 cM
Alliance: Rragatm1.1Dmsa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:194401
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129 and C57BL/6
Mutation
description
Allele Type:    Targeted (Constitutively active)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA floxed hygromycin resistance/STOP cassette was inserted upstream of a modified coding exon in which an A to T transversion results in the amino acid substitution of lysine for glutamine at position 66 (Q66L). Cre-mediated recombination removed the hygromycin resistance/STOP cassette. The predicted protein is constitutively active. (J:194401)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rraga Mutation:  17 strains or lines available
References
Original:  J:194401 Efeyan A, et al., Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival. Nature. 2013 Jan 31;493(7434):679-83
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory