Apoe^tm1Rraf
Targeted Allele Detail

Summary

• Symbol: Apoe^tm1Rraf
• Name: apolipoprotein E; targeted mutation 1, David L Raffai
• MGI ID: MGI:5499980
• Synonyms: ApoeT^h
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^tm1Rraf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196923
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: A floxed neomycin resistance cassette was inserted downstream of the exon 3. This allele is hypomorphic due to the presence of the floxed neomycin resistance cassette. (J:196923)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 158 strains or lines available

References

• Original: J:196923 Eberle D, et al., Apolipoprotein E4 domain interaction accelerates diet-induced atherosclerosis in hypomorphic Arg-61 apoe mice. Arterioscler Thromb Vasc Biol. 2012 May;32(5):1116-23
• All: 1 reference(s)