Slc25a23^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Slc25a23^tm1Lex
• Name: solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5500043
• Gene: Slc25a23 Location: Chr17:57350711-57366863 bp, - strand Genetic Position: Chr17, 29.64 cM
• Alliance: Slc25a23^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196890
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Not Specified
• Mutation details: No description provided. Western blot analysis confirmed the absence of protein expression in the liver, brain, heart and muscle. (J:196890)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
hm1	Slc25a23^tm1Lex/Slc25a23^tm1Lex	involves: 129 * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cellular	√
abnormal mitochondrial physiology	√
homeostasis/metabolism	√
decreased urine urea nitrogen level	√
renal/urinary system	√
decreased urine urea nitrogen level	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc25a23 Mutation: 36 strains or lines available

References

• Original: J:196890 Amigo I, et al., Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3. J Biol Chem. 2013 Mar 15;288(11):7791-802
• All: 3 reference(s)