Trpm2^tm1.1Jych
Targeted Allele Detail

Summary

• Symbol: Trpm2^tm1.1Jych
• Name: transient receptor potential cation channel, subfamily M, member 2; targeted mutation 1.1, Joseph Y Cheung
• MGI ID: MGI:5500054
• Synonyms: TRPM2⁰
• Gene: Trpm2 Location: Chr10:77743556-77805746 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Trpm2^tm1.1Jych page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196475
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 21 and 22 were floxed and subsequently removed by cre-mediated recombination. This allele is predicted to produce a premature stop codon in exon 23. RT-PCR confirmed the absence of transcript expression in the heart. (J:196475)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm2 Mutation: 112 strains or lines available

References

• Original: J:196475 Miller BA, et al., The second member of transient receptor potential-melastatin channel family protects hearts from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H1010-22
• All: 4 reference(s)