Lin28a^tm1.1Gqda
Targeted Allele Detail

Summary

• Symbol: Lin28a^tm1.1Gqda
• Name: lin-28 homolog A; targeted mutation 1.1, George Q Daley
• MGI ID: MGI:5500060
• Gene: Lin28a Location: Chr4:133730641-133746152 bp, - strand Genetic Position: Chr4, 66.5 cM
• Alliance: Lin28a^tm1.1Gqda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196313
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT flanked neo cassette with a 5' loxP site was inserted downstream of exon 2 via homologous recombination. Cre-mediated recombination removed exon 2. (J:196313)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lin28a Mutation: 76 strains or lines available

References

• Original: J:196313 Shinoda G, et al., Lin28a regulates germ cell pool size and fertility. Stem Cells. 2013 May;31(5):1001-9
• All: 2 reference(s)