Myod1^tm2Glh
Targeted Allele Detail

Summary

• Symbol: Myod1^tm2Glh
• Name: myogenic differentiation 1; targeted mutation 2, David J Goldhamer
• MGI ID: MGI:5500171
• Synonyms: DRR^neo
• Gene: Myod1 Location: Chr7:46025898-46028516 bp, + strand Genetic Position: Chr7, 30.03 cM
• Alliance: Myod1^tm2Glh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76260
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.9-kb genomic fragment containing the 714-bp downstream regulatory region was replaced with a PGKneo-positive selection cassette flanked by loxP sites. Whole-mount in situ hybridization and northern blot analysis confirmed reduced transcript expression in all myogenic population. (J:76260)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myod1 Mutation: 24 strains or lines available

References

• Original: J:76260 Chen JC, et al., Essential and redundant functions of the MyoD distal regulatory region revealed by targeted mutagenesis. Dev Biol. 2002 May 1;245(1):213-23
• All: 2 reference(s)