Ros1^tm1.1Char
Targeted Allele Detail

Summary

• Symbol: Ros1^tm1.1Char
• Name: Ros1 proto-oncogene; targeted mutation 1.1, Alain Charest
• MGI ID: MGI:5500177
• Synonyms: ROS1^KM
• Gene: Ros1 Location: Chr10:51921817-52071340 bp, - strand Genetic Position: Chr10, 26.18 cM
• Alliance: Ros1^tm1.1Char page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211844
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Single point mutation
• Mutation details: The gene was targeted with a construct containing a FRT-flanked neomycin resistance cassette and a point mutation that changes the triplet encoding lysine at amino acid position 1973 of the protein to a methionine codon (K1973M). Germline expression of enhanced FLP recombinase resulted in deletion of neomycin resistance cassette, leaving a single FRT site and the point mutation. The protein product lacks kinase activity in the absence of phosphorylation. (J:211844)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ros1 Mutation: 145 strains or lines available

References

• Original: J:211844 Jun HJ, et al., ROS1 Signaling Regulates Epithelial Differentiation in the Epididymis. Endocrinology. 2014 Jun 27;:en20141341
• All: 1 reference(s)