Cul4b^tm1.1Yxg
Targeted Allele Detail

Summary

• Symbol: Cul4b^tm1.1Yxg
• Name: cullin 4B; targeted mutation 1, Yaoqin Gong
• MGI ID: MGI:5500947
• Synonyms: Cul4b^null
• Gene: Cul4b Location: ChrX:37622151-37665073 bp, - strand Genetic Position: ChrX, 22.81 cM, cytoband A2
• Alliance: Cul4b^tm1.1Yxg page

Early developmental arrest in Cul4b^tm1.1Yxg/Y embryos

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199139
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exons 3 through 5. Immunohistochemistry confirmed the absence of protein expression in embryos. (J:199139)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cul4b Mutation: 37 strains or lines available

References

• Original: J:199139 Jiang B, et al., Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development. PLoS One. 2012;7(5):e37070
• All: 4 reference(s)