Lyn^m1Anu
Chemically induced Allele Detail

Summary

• Symbol: Lyn^m1Anu
• Name: LYN proto-oncogene, Src family tyrosine kinase; mutation 1, Australian National University
• MGI ID: MGI:5501039
• Synonyms: ENU16CH17a, Lyn^m1Apb, Lyn^T410A
• Gene: Lyn Location: Chr4:3676865-3791613 bp, + strand Genetic Position: Chr4, 2.05 cM
• Alliance: Lyn^m1Anu page

Mutation origin

• Strain of Origin: C57BL/6JAnu

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced an A to G transition in exon 12 that results in the amino acid substitution of alanine for threonine at position 410 (T410A). (J:195155)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lyn Mutation: 65 strains or lines available

Notes

A non-causative mutation is detected in the founder line within Tlr4. J:195155

References

• Original: J:195155 Bull KR, et al., Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. PLoS Genet. 2013 Jan;9(1):e1003219
• All: 4 reference(s)