Nkx6-1^tm1.1Msan
Targeted Allele Detail

Summary

• Symbol: Nkx6-1^tm1.1Msan
• Name: NK6 homeobox 1; targeted mutation 1.1, Maike Sander
• MGI ID: MGI:5501129
• Synonyms: Nkx6.1^flox
• Gene: Nkx6-1 Location: Chr5:101807050-101812577 bp, - strand Genetic Position: Chr5, 48.84 cM
• Alliance: Nkx6-1^tm1.1Msan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195153
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance (neo) cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. (J:195153)

Generation of the Nkx6-1^tm1.1Msan and Nkx6-1^tm1.2Msan alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nkx6-1 Mutation: 4 strains or lines available

References

• Original: J:195153 Schaffer AE, et al., Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet. 2013 Jan;9(1):e1003274
• All: 4 reference(s)