Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan
Transgene Detail

Summary

• Symbol: Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan
• Name: transgene insertion, Maike Sander
• MGI ID: MGI:5501130
• Synonyms: CAG-Bgeo,-Nkx6.1,-eGFP, Nkx6.1^OE
• Transgene: Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan Location: unknown
• Alliance: Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan page

Transgene origin

• Strain of Origin: (BALB/c x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Nkx6-1 (MGI:1206039)

• Mutation details: The CAG promoter drives ubiquitous expression of the mouse cDNA and IRES-EGFP preceded by a floxed beta-geo cassette. Two founder lines were established. The pound symbol (#) is used when no line is specified and/or lines are pooled. Cre-mediated recombination is required to removed the beta-geo cassette and allow for over-expression of the cDNA. (J:163847)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:163847 Schaffer AE, et al., Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors. Dev Cell. 2010 Jun 15;18(6):1022-9
• All: 4 reference(s)