Nkx6-1^tm1.2Msan
Targeted Allele Detail

Summary

• Symbol: Nkx6-1^tm1.2Msan
• Name: NK6 homeobox 1; targeted mutation 1.2, Maike Sander
• MGI ID: MGI:5501147
• Synonyms: Nkx6.1^deltaf
• Gene: Nkx6-1 Location: Chr5:101807050-101812577 bp, - strand Genetic Position: Chr5, 48.84 cM
• Alliance: Nkx6-1^tm1.2Msan page

The gross morphology of Nkx6-1^tm1Jlr/Nkx6-1^tm1.2Msan embryos at E18.5

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195153
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance (neo) cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. (J:195153)

Generation of the Nkx6-1^tm1.1Msan and Nkx6-1^tm1.2Msan alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx6-1 Mutation: 4 strains or lines available

References

• Original: J:195153 Schaffer AE, et al., Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. PLoS Genet. 2013 Jan;9(1):e1003274
• All: 1 reference(s)