Birc2^tm2.1Jda
Targeted Allele Detail

Summary

• Symbol: Birc2^tm2.1Jda
• Name: baculoviral IAP repeat-containing 2; targeted mutation 2.1, Jonathan D Ashwell
• MGI ID: MGI:5501232
• Synonyms: c-IAP2^H570A, c-IAP2^ki
• Gene: Birc2 Location: Chr9:7818228-7837065 bp, - strand Genetic Position: Chr9, 2.46 cM, cytoband A1
• Alliance: Birc2^tm2.1Jda page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199221
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A targeting construct was designed to insert a loxP- and frt-flanked neomycin (neo) resistance cassette downstream of exon 7. A point mutation was introduced in exon 7, encoding a RING domain, resulting in an H582A mutation. Cre-mediated recombination removed the neo cassette. (J:199221)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Birc2 Mutation: 33 strains or lines available

References

• Original: J:199221 Giardino Torchia ML, et al., c-IAP1 and c-IAP2 Redundancy Differs between T and B Cells. PLoS One. 2013;8(6):e66161
• All: 1 reference(s)