Nfkbiz^tm1.1Muta
Targeted Allele Detail

Summary

• Symbol: Nfkbiz^tm1.1Muta
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta; targeted mutation 1.1, Tatsushi Muta
• MGI ID: MGI:5501251
• Gene: Nfkbiz Location: Chr16:55631740-55659018 bp, - strand Genetic Position: Chr16, 33.65 cM, cytoband C1.2-C1.3
• Alliance: Nfkbiz^tm1.1Muta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194832
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 4 and an FRT flanked neomycin selection cassette followed by a second loxP site was inserted in intron 7. The selection cassette was excised from properly targeted mice by flp recombinase. (J:194832)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfkbiz Mutation: 33 strains or lines available

References

• Original: J:194832 Okuma A, et al., Enhanced Apoptosis by Disruption of the STAT3-IkappaB-zeta Signaling Pathway in Epithelial Cells Induces Sjogren's Syndrome-like Autoimmune Disease. Immunity. 2013 Mar 21;38(3):450-60
• All: 11 reference(s)