Srxn1^tm1Mtol
Targeted Allele Detail

Summary

• Symbol: Srxn1^tm1Mtol
• Name: sulfiredoxin 1 homolog (S. cerevisiae); targeted mutation 1, Mireille B Toledano
• MGI ID: MGI:5501480
• Synonyms: Srx^-
• Gene: Srxn1 Location: Chr2:151947436-151953296 bp, + strand Genetic Position: Chr2, 74.83 cM, cytoband H1
• Alliance: Srxn1^tm1Mtol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199277
• Parent Cell Line: AT1 (ES Cell)
• Strain of Origin: 129S2/SvPasCrl

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 2. Western blot analysis confirmed the absence of protein expression in the liver. (J:199277)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Srxn1^tm1Mtol

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srxn1 Mutation: 9 strains or lines available

References

• Original: J:199277 Planson AG, et al., Sulfiredoxin protects mice from lipopolysaccharide-induced endotoxic shock. Antioxid Redox Signal. 2011 Jun;14(11):2071-80
• All: 5 reference(s)