Vdr^tm2.1Ska
Targeted Allele Detail

Summary

• Symbol: Vdr^tm2.1Ska
• Name: vitamin D (1,25-dihydroxyvitamin D3) receptor; targeted mutation 2.1, Shigeaki Kato
• MGI ID: MGI:5501514
• Synonyms: VDR^L-, Vdr^tm1.1Pcn
• Gene: Vdr Location: Chr15:97752308-97806177 bp, - strand Genetic Position: Chr15, 53.85 cM
• Alliance: Vdr^tm2.1Ska page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196471
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neomycin (neo) resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed the neo cassette and exon 3. (J:196471)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vdr Mutation: 36 strains or lines available

References

• Original: J:196471 Yamamoto Y, et al., Vitamin D receptor in osteoblasts is a negative regulator of bone mass control. Endocrinology. 2013 Mar;154(3):1008-20
• All: 2 reference(s)