Zfp148^tm1.1Jmer
Targeted Allele Detail

Summary

• Symbol: Zfp148^tm1.1Jmer
• Name: zinc finger protein 148; targeted mutation 1.1, Juanita L Merchant
• MGI ID: MGI:5502212
• Synonyms: ZBP-89^FL
• Gene: Zfp148 Location: Chr16:33201145-33324273 bp, + strand Genetic Position: Chr16, 23.93 cM
• Alliance: Zfp148^tm1.1Jmer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198847
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin (neo) resistance cassette with a 5' loxP site was inserted upstream of exon 8. An additional loxP site was inserted into the 3' UTR in exon 9. Flp-mediated recombination removed the neo cassette and left the coding sequence in exon 8 and 9 floxed. (J:198847)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp148 Mutation: 112 strains or lines available

References

• Original: J:198847 Essien BE, et al., ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice. Gastroenterology. 2013 Jun;144(7):1466-77, 1477.e1-9
• All: 4 reference(s)