Plin2^tm1.1Asg
Targeted Allele Detail

Summary

• Symbol: Plin2^tm1.1Asg
• Name: perilipin 2; targeted mutation 1.1, Andrew Greenberg
• MGI ID: MGI:5502311
• Synonyms: Plin2^delta5
• Gene: Plin2 Location: Chr4:86566623-86588297 bp, - strand Genetic Position: Chr4, 40.69 cM
• Alliance: Plin2^tm1.1Asg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196302
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 5. Western blot analysis confirmed the absence of protein expression in the liver of fed and fasted mice. (J:196302)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plin2 Mutation: 38 strains or lines available

References

• Original: J:196302 McManaman JL, et al., Perilipin-2-null mice are protected against diet-induced obesity, adipose inflammation, and fatty liver disease. J Lipid Res. 2013 May;54(5):1346-59
• All: 4 reference(s)