Nabp2^tm1.1Kkha
Targeted Allele Detail

Summary

• Symbol: Nabp2^tm1.1Kkha
• Name: nucleic acid binding protein 2; targeted mutation 1.1, Kum Kum Khanna
• MGI ID: MGI:5502334
• Synonyms: Ssb1^fl
• Gene: Nabp2 Location: Chr10:128237264-128247361 bp, - strand Genetic Position: Chr10, 76.55 cM, cytoband D3
• Alliance: Nabp2^tm1.1Kkha page

Testicular degeneration in Nabp2^tm1.1Kkha/Nabp2^tm1.1Kkha Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195140
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Exons 3 through 6 were floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette and left exons 3 through 6 floxed. (J:195140)

Generation of the Nabp2^tm1.1Kkha and Nabp2^tm1.2Kkha alleles

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nabp2 Mutation: 16 strains or lines available

References

• Original: J:195140 Shi W, et al., Essential developmental, genomic stability, and tumour suppressor functions of the mouse orthologue of hSSB1/NABP2. PLoS Genet. 2013 Feb;9(2):e1003298
• All: 3 reference(s)