Tg(LRRK2*G2019S)2AMjff
Transgene Detail

Summary

• Symbol: Tg(LRRK2*G2019S)2AMjff
• Name: transgene insertion 2A, The Michael J Fox Foundation
• MGI ID: MGI:5502368
• Synonyms: Tg(LRRK2*G2019S)2AGrsr
• Transgene: Tg(LRRK2*G2019S)2AMjff Location: Chr2:80726749-80726750 bp Genetic Position: Chr2, 8.0896408E7 cM
• Alliance: Tg(LRRK2*G2019S)2AMjff page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Nucleotide substitutions
• Tg(LRRK2*G2019S)2AMjff expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LRRK2 (120892)

  Lrrk2

  (MGI:1913975)

• Mutation details: A 188 kb bacterial artificial chromosome (BAC) containing the entire human LRRK2 (leucine-rich repeat kinase 2) gene was modified by targeted mutation of the LRRK2 locus to harbor the LRRK2 G2019S mutation associated with autosomal dominant, late-onset Parkinson's disease originally identified in Spanish families originating from the Basque region. (J:101977)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 14 reference(s)