Gp6^{tm1.1(GP6)Ics}
Targeted Allele Detail

Summary

• Symbol: Gp6^{tm1.1(GP6)Ics}
• Name: glycoprotein 6 platelet; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5502382
• Gene: Gp6 Location: Chr7:4366964-4400743 bp, - strand Genetic Position: Chr7, 2.52 cM
• Alliance: Gp6^{tm1.1(GP6)Ics} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199351
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting construct containing the human GP6 cDNA coding sequence was introduced into exon 1 at the ATG start site. The human sequence was followed by a polyadenylation sequence and floxed neomycin resistance cassette. Cre-mediated recombination removed the neo cassette. (J:199351)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gp6 Mutation: 19 strains or lines available

References

• Original: J:199351 Mangin PH, et al., A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents. J Pharmacol Exp Ther. 2012 Apr;341(1):156-63
• All: 2 reference(s)