Pax1^tm2.1Tlu
Targeted Allele Detail

Summary

• Symbol: Pax1^tm2.1Tlu
• Name: paired box 1; targeted mutation 2.1, Thomas Lufkin
• MGI ID: MGI:5502389
• Synonyms: Pax1^EGFP:Pax1-
• Gene: Pax1 Location: Chr2:147203850-147216972 bp, + strand Genetic Position: Chr2, 72.63 cM
• Alliance: Pax1^tm2.1Tlu page

Pax1^tm2.1Tlu/Pax1^tm2.1Tlu mice are slightly shorter, with a short kinked tail

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198603
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: An RAKR furin motif sequence to trim the residual 2A peptide from the upstream protein, glycine-serine-glycine (GCG) spacer, foot-and-mouth disease virus 2A peptide (F2A) sequence, EGFP and FRT-flanked neomycin resistance (neo) cassette were inserted into intron 2. Flp-mediated recombination removed the neo cassette. (J:198603)

Generation of the Pax1^tm2.1Tlu allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax1 Mutation: 28 strains or lines available

References

• Original: J:198603 Sivakamasundari V, et al., Pax1(EGFP) : New wildtype and mutant EGFP mouse lines for molecular and fate mapping studies. Genesis. 2013 Jun;51(6):420-9
• All: 2 reference(s)