Dlx1as^tm1.1Tlu
Targeted Allele Detail

Summary

• Symbol: Dlx1as^tm1.1Tlu
• Name: distal-less homeobox 1, antisense; targeted mutation 1.1, Thomas Lufkin
• MGI ID: MGI:5502415
• Synonyms: Dlx1as^4xPA
• Gene: Dlx1as Location: Chr2:71360982-71368235 bp, - strand Genetic Position: Chr2, 42.58 cM
• Alliance: Dlx1as^tm1.1Tlu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195139
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neomycin resistance (neo) cassette with four polyadenylation sites. Cre-mediated recombination removed the neo cassette. This insertion does not affect the Dlx1 sense transcript. QRT-PCR confirmed the absence of transcript expression in the brain. (J:195139)

Expression

In Mice Carrying this Mutation:	36 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlx1as Mutation: 0 strains or lines available

References

• Original: J:195139 Kraus P, et al., Making sense of Dlx1 antisense RNA. Dev Biol. 2013 Apr 15;376(2):224-35
• All: 1 reference(s)