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Gbx1tm1.1Stwt
Targeted Allele Detail
Summary
Symbol: Gbx1tm1.1Stwt
Name: gastrulation brain homeobox 1; targeted mutation 1.1, Samuel T Waters
MGI ID: MGI:5502431
Gene: Gbx1  Location: Chr5:24709424-24731846 bp, - strand  Genetic Position: Chr5, 11.93 cM
Alliance: Gbx1tm1.1Stwt page
Locomotive defect affecting hindlimb gait in Gbx1tm1.1Stwt/Gbx1tm1.1Stwt mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197199
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT-flanked neo cassette with a 3' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2. Whole mount in situ hybrizidation confirmed the absence of transcript expression in E9.5 embryos. (J:197199)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 22 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gbx1 Mutation:  19 strains or lines available
References
Original:  J:197199 Buckley DM, et al., Characterization of the Gbx1-/- mouse mutant: a requirement for Gbx1 in normal locomotion and sensorimotor circuit development. PLoS One. 2013;8(2):e56214
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory