Gt(ROSA)26Sor^tm1Jus
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1Jus
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Monica Justice
• MGI ID: MGI:5502574
• Synonyms: Gt(ROSA)26Sor^{tm1(LSL-Prdm14-IRES-EGFP)Jus}, Gt(ROSA)26Sor^{tm1(Prdm14)Jus}, R26PR
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1Jus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202090
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^tm1Jus expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prdm14 (MGI:3588194)

• Mutation details: A loxP-PGK/Neo/pA-3XpA(STOP)-loxP-Prdm14-IRES-EGFP targeted to the locus. This allele provides a model for cre-inducible overexpression of Prdm14 and the EGFP marker. (J:202090)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:202090 Carofino BL, et al., A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). Dis Model Mech. 2013 Nov-Dec;6(6):1494-506
• All: 3 reference(s)