Hsd11b1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Hsd11b1^tm1Lex
• Name: hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5502586
• Gene: Hsd11b1 Location: Chr1:192903917-192946345 bp, - strand Genetic Position: Chr1, 97.67 cM
• Alliance: Hsd11b1^tm1Lex page

Decreased aortic root atherosclerosis susceptibility in Apoe^tm1Unc/Apoe^tm1Unc Hsd11b1^tm1Lex/Hsd11b1^tm1Lex mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199430
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A lacZ/neomycin resistance cassette replaced exons 4 and 5. QRT-PCR confirmed the absence of transcript expression in the liver, adipose, spleen and macrophage. (J:199430)

Generation of the Hsd11b1^tm1Lex allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hsd11b1 Mutation: 28 strains or lines available

References

• Original: J:199430 Garcia RA, et al., 11beta-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE(-)/(-) mice. PLoS One. 2013;8(2):e53192
• All: 1 reference(s)