Ank1^ity16
Chemically induced Allele Detail

Summary

• Symbol: Ank1^ity16
• Name: ankyrin 1, erythroid; immunity to Typhimurium locus 16
• MGI ID: MGI:5502651
• Gene: Ank1 Location: Chr8:23464860-23640513 bp, + strand Genetic Position: Chr8, 11.42 cM
• Alliance: Ank1^ity16 page

Extensive extramedullary erythropoiesis in the spleen and liver, severe lymphoid depletion, and increase in iron pigment deposition the liver and kidney of Ank1^ity16/Ank1^ity16 mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: 129S1/Sv

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: ENU-induced a missense mutation (c.4069C>T) that results in the amino acid substitution of a stop codon for glutamine at position 1357 (Q1357X). (J:199427)

ENU mutagenesis produces a C to T transition at position 4069 resulting in the Ank1^ity16 mutant

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ank1 Mutation: 106 strains or lines available

References

• Original: J:199427 Yuki KE, et al., Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant. PLoS One. 2013;8(2):e55331
• All: 1 reference(s)