Polg^tm1Jiha
Targeted Allele Detail

Summary

• Symbol: Polg^tm1Jiha
• Name: polymerase (DNA directed), gamma; targeted mutation 1, Jun-Ichi Hayashi
• MGI ID: MGI:5502688
• Synonyms: m mutator, mtDNA mutator
• Gene: Polg Location: Chr7:79095979-79116110 bp, - strand Genetic Position: Chr7, 45.04 cM, cytoband E
• Alliance: Polg^tm1Jiha page

Kyphosis in Polg^tm1Jiha/Polg^tm1Jiha and Del(MTmt-Tk-mt-Nd5)1Jiha mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199416
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Nucleotide substitutions (GACCGA to GCGCGC) to introduce the amino acid substitution of alanine for aspartic acid at position 257 (D257A) and create a BssHII site for genotyping. (J:199416)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Polg Mutation: 58 strains or lines available

References

• Original: J:199416 Mito T, et al., Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development. PLoS One. 2013;8(2):e55789
• All: 2 reference(s)