Tab3^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Tab3^tm1Aki
• Name: TGF-beta activated kinase 1/MAP3K7 binding protein 3; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:5502690
• Gene: Tab3 Location: ChrX:84617628-84678075 bp, + strand Genetic Position: ChrX, 39.32 cM, cytoband B
• Alliance: Tab3^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195289
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Almost all of exons 2 and 3 were replaced by a neomycin resistance cassette. Absence of mRNA in properly targeted mice was confirmed by PCR. (J:195289)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tab3 Mutation: 13 strains or lines available

References

• Original: J:195289 Ori D, et al., Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs. J Immunol. 2013 Apr 15;190(8):4037-45
• All: 1 reference(s)