Ighg1^tm1.1Pyu
Targeted Allele Detail

Summary

• Symbol: Ighg1^tm1.1Pyu
• Name: immunoglobulin heavy constant gamma 1 (G1m marker); targeted mutation 1.1, Philipp Yu
• MGI ID: MGI:5502698
• Synonyms: freac, IgE^ki
• Gene: Ighg1 Location: Chr12:113290161-113294143 bp, - strand Genetic Position: Chr12, 62.1 cM
• Alliance: Ighg1^tm1.1Pyu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198154
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Endogenous IgG1 exons (G1 -3) were replaced with IgE exons (E1-4), a floxed neomycin resistance cassette, IgG1 exons G1-3 and a loxP site. Cre-mediated recombination removed the neo cassette and the exogenous IgG1 exons G1-3. (J:198154)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ighg1 Mutation: 28 strains or lines available

References

• Original: J:198154 Lubben W, et al., IgE knock-in mice suggest a role for high levels of IgE in basophil-mediated active systemic anaphylaxis. Eur J Immunol. 2013 Apr;43(5):1231-42
• All: 2 reference(s)