Pycr2^m1J
Chemically induced Allele Detail

Summary

• Symbol: Pycr2^m1J
• Name: pyrroline-5-carboxylate reductase family, member 2; mutation 1, Jackson
• MGI ID: MGI:5502703
• Synonyms: Pycr2^-
• Gene: Pycr2 Location: Chr1:180731858-180735653 bp, + strand Genetic Position: Chr1, 84.46 cM, cytoband H5
• Alliance: Pycr2^m1J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: Analysis of exome sequencing for this mutation showed a c.2T>C single nucleotide substitution at position GRCm39:chr1:g.180732030T>C, changing the start codon to a threonine codon (p.Met1Thr). Western blot analysis demonstrated absence of protein in the brain and spinal cord of homozygous mutant mice. (J:308336)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pycr2 Mutation: 23 strains or lines available

References

• Original: J:308336 Stum MG, et al., Genetic analysis of Pycr1 and Pycr2 in mice. Genetics. 2021 May 17;218(1)
• All: 1 reference(s)