Kcnh1^tm1.1Ruf
Targeted Allele Detail

Summary

• Symbol: Kcnh1^tm1.1Ruf
• Name: potassium voltage-gated channel, subfamily H (eag-related), member 1; targeted mutation 1.1, Roser Ufartes
• MGI ID: MGI:5502738
• Synonyms: Kv10.1^-
• Gene: Kcnh1 Location: Chr1:191873082-192192467 bp, + strand Genetic Position: Chr1, 97.33 cM
• Alliance: Kcnh1^tm1.1Ruf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198153
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 7. An additional loxP site was inserted downstream of exon 7. Cre-mediated recombination removed the neo cassette and exon 7. Western blot analysis confirmed the absence of protein expression in the brain. (J:198153)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnh1 Mutation: 56 strains or lines available

References

• Original: J:198153 Ufartes R, et al., Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice. Hum Mol Genet. 2013 Jun 1;22(11):2247-62
• All: 2 reference(s)