Rheb^tm1.1Otsu
Targeted Allele Detail

Summary

• Symbol: Rheb^tm1.1Otsu
• Name: Ras homolog enriched in brain; targeted mutation 1.1, Kinya Otsu
• MGI ID: MGI:5502740
• Synonyms: Rheb^flox
• Gene: Rheb Location: Chr5:25007821-25047359 bp, - strand Genetic Position: Chr5, 11.93 cM
• Alliance: Rheb^tm1.1Otsu page

Sarcomere maturation is attenuated in Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0 hearts

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197831
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 and C57BL/6J

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exon 3 floxed. (J:197831)

Generation of the Rheb^tm1.1Otsu allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rheb Mutation: 26 strains or lines available

References

• Original: J:197831 Tamai T, et al., Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period. J Biol Chem. 2013 Apr 5;288(14):10176-87
• All: 1 reference(s)