Sh2d1a^tm1.1Knic
Targeted Allele Detail

Summary

• Symbol: Sh2d1a^tm1.1Knic
• Name: SH2 domain containing 1A; targeted mutation 1.1, Kim E Nichols
• MGI ID: MGI:5502752
• Synonyms: Sap^fl
• Gene: Sh2d1a Location: ChrX:41591442-41610974 bp, + strand Genetic Position: ChrX, 23.2 cM, cytoband A5
• Alliance: Sh2d1a^tm1.1Knic page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196692
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 1 was floxed. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:196692)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d1a Mutation: 11 strains or lines available

References

• Original: J:196692 Das R, et al., The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation. Blood. 2013 Apr 25;121(17):3386-95
• All: 1 reference(s)