Gt(ROSA)26Sor^{tm1(CAG-NPM1*)Geno}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-NPM1*)Geno}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Genoway
• MGI ID: MGI:5502770
• Synonyms: Npm1-TCTG
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-NPM1*)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196690
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-NPM1*)Geno} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  NPM1 (4869)

  Npm1	(MGI:106184)

• Mutation details: The targeting contruct inserted into the locus contained a CAG promoter, floxed neomycin resistance and STOP cassette, and the human cDNA with a TCTG duplication at positions 956 to 959 in exon 12 (GenBank accession number NM_002520). This mutation is the most frequent mutation of the NPM1 gene in patients with acute myeloid leukemia (AML). (J:196690)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:196690 Sportoletti P, et al., The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model. Blood. 2013 Apr 25;121(17):3447-58
• All: 2 reference(s)