Smap1^tm1.1Sata
Targeted Allele Detail

Summary

• Symbol: Smap1^tm1.1Sata
• Name: small ArfGAP 1; targeted mutation 1.1, Masanobu Satake
• MGI ID: MGI:5503229
• Synonyms: Smap1^-
• Gene: Smap1 Location: Chr1:23883927-23961398 bp, - strand Genetic Position: Chr1, 9.79 cM, cytoband A5
• Alliance: Smap1^tm1.1Sata page

Hematological abnormalities in Smap1^tm1.1Sata/Smap1^tm1.1Sata mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196385
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the bone marrow. (J:196385)

Generation of the Smap1^tm1.1Sata allele

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smap1 Mutation: 28 strains or lines available

References

• Original: J:196385 Kon S, et al., Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia. J Clin Invest. 2013 Mar 1;123(3):1123-37
• All: 2 reference(s)