Slc5a10^tm1Csk
Targeted Allele Detail

Summary

• Symbol: Slc5a10^tm1Csk
• Name: solute carrier family 5 (sodium/glucose cotransporter), member 10; targeted mutation 1, Chugai Pharmaceutical Co, Ltd
• MGI ID: MGI:5503305
• Gene: Slc5a10 Location: Chr11:61563608-61611641 bp, - strand Genetic Position: Chr11, 37.96 cM
• Alliance: Slc5a10^tm1Csk page

Increase in liver triglyceride levels in Slc5a10^tm1Csk/Slc5a10^tm1Csk mice fed a high fructose diet

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199406
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion A neomycin resistance cassette replaced part of exon 3 through part of exon 6. (J:199406)

Generation of the Slc5a10^tm1Csk allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc5a10 Mutation: 20 strains or lines available

References

• Original: J:199406 Fukuzawa T, et al., SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose. PLoS One. 2013;8(2):e56681
• All: 1 reference(s)