Ggn^tm1Dpj
Targeted Allele Detail

Summary

• Symbol: Ggn^tm1Dpj
• Name: gametogenetin; targeted mutation 1, Duangporn Jamsai
• MGI ID: MGI:5503309
• Gene: Ggn Location: Chr7:28869635-28873363 bp, + strand Genetic Position: Chr7, 16.94 cM
• Alliance: Ggn^tm1Dpj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199404
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A kanamycin/neomycin resistance cassette replaced the coding sequence. Western blot analysis confirmed reduced protein expression in spermatocytes from heterozygotes. (J:199404)

Generation of the Ggn^tm1Dpj allele

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ggn Mutation: 23 strains or lines available

References

• Original: J:199404 Jamsai D, et al., Loss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouse. PLoS One. 2013;8(2):e56955
• All: 1 reference(s)