Nf2^tm2Gvn
Targeted Allele Detail

Summary

• Symbol: Nf2^tm2Gvn
• Name: neurofibromin 2; targeted mutation 2, Marco Giovannini
• MGI ID: MGI:5504370
• Synonyms: Nf2-iso2^-
• Gene: Nf2 Location: Chr11:4715845-4799536 bp, - strand Genetic Position: Chr11, 3.0 cM
• Alliance: Nf2^tm2Gvn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197562
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Not Specified
• Mutation details: An isoform 2-specific knock-out was generated. Western blot analysis confirmed reduced neurofilament phosphorylation in the brain. (J:197562)

Tumor Data

List all tumor models in MMHCdb carrying Nf2^tm2Gvn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nf2 Mutation: 65 strains or lines available

References

• Original: J:197562 Schulz A, et al., Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nat Neurosci. 2013 Apr;16(4):426-33
• All: 3 reference(s)