Map2k1^tm1.1Bacc
Targeted Allele Detail

Summary

• Symbol: Map2k1^tm1.1Bacc
• Name: mitogen-activated protein kinase kinase 1; targeted mutation 1.1, Manuela Baccarini
• MGI ID: MGI:5504393
• Gene: Map2k1 Location: Chr9:64093066-64160887 bp, - strand Genetic Position: Chr9, 34.55 cM
• Alliance: Map2k1^tm1.1Bacc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199705
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neomycin resistance cassette and exon 2. (J:199705)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map2k1 Mutation: 94 strains or lines available

References

• Original: J:199705 Catalanotti F, et al., A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. Nat Struct Mol Biol. 2009 Mar;16(3):294-303
• All: 3 reference(s)