Sox3^tm1Pqt
Targeted Allele Detail

Summary

• Symbol: Sox3^tm1Pqt
• Name: SRY (sex determining region Y)-box 3; targeted mutation 1, Paul Q Thomas
• MGI ID: MGI:5504449
• Synonyms: Sox3-26ala, Sox3^tm1Ptho
• Gene: Sox3 Location: ChrX:59934972-59937036 bp, - strand Genetic Position: ChrX, 33.66 cM, cytoband A7.3-B
• Alliance: Sox3^tm1Pqt page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:195300
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: A 36 bp expansion of the first polyalanine tract expanded the tract from 14 to 26 alanines. Morula injection resulted in chimeras with up to 95% mutant cell contribution. In addition, an FRT flanked neo selection cassette was inserted downstream. Despite extensive breeding, none of these chimeras exhibited germline transmission of the mutant allele. (J:195300)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox3 Mutation: 7 strains or lines available

References

• Original: J:195300 Hughes J, et al., Mechanistic insight into the pathology of polyalanine expansion disorders revealed by a mouse model for X linked hypopituitarism. PLoS Genet. 2013 Mar;9(3):e1003290
• All: 1 reference(s)