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Washc1tm1.2Ddb
Targeted Allele Detail
Summary
Symbol: Washc1tm1.2Ddb
Name: WASH complex subunit 1; targeted mutation 1.2, Daniel D Billadeau
MGI ID: MGI:5504472
Gene: Washc1  Location: Chr17:66418540-66427498 bp, + strand  Genetic Position: Chr17, 35.26 cM, cytoband F3-F4
Alliance: Washc1tm1.2Ddb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199703
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. (J:199703)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Washc1 Mutation:  13 strains or lines available
References
Original:  J:199703 Gomez TS, et al., Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks. Mol Biol Cell. 2012 Aug;23(16):3215-28
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory