Lamc1^tm1.2Strl
Targeted Allele Detail

Summary

• Symbol: Lamc1^tm1.2Strl
• Name: laminin, gamma 1; targeted mutation 1.2, Sidney Strickland
• MGI ID: MGI:5504479
• Gene: Lamc1 Location: Chr1:153094668-153208532 bp, - strand Genetic Position: Chr1, 65.3 cM
• Alliance: Lamc1^tm1.2Strl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199683
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked by single loxP sites. An frt flanked neomycin resistance cassette was inserted upstream of the floxed region, in intron 1. Cre-mediated recombination removed exon 2. (J:199683)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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ht1	Lamc1^tm1Strl/Lamc1^tm1.2Strl	either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)

Phenotypes:

Affected Systems	ht1
show or hide all annotated terms
behavior/neurological	√
limb grasping	√
paraparesis	√
cellular	√
abnormal basement membrane morphology	√
limbs/digits/tail	√
abnormal quadriceps morphology	√
muscle	√
abnormal quadriceps morphology	√
decreased skeletal muscle fiber diameter	√
centrally nucleated skeletal muscle fibers	√
decreased skeletal muscle mass	√
skeletal muscle fiber atrophy	√
nervous system	√
increased Schwann cell number	√
demyelination	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamc1 Mutation: 143 strains or lines available

References

• Original: J:199683 McKee KK, et al., Schwann cell myelination requires integration of laminin activities. J Cell Sci. 2012 Oct 1;125(Pt 19):4609-19
• All: 1 reference(s)