Lamc1^tm1.1Strl
Targeted Allele Detail

Summary

• Symbol: Lamc1^tm1.1Strl
• Name: laminin, gamma 1; targeted mutation 1.1, Sidney Strickland
• MGI ID: MGI:5504480
• Synonyms: LAMC1 fl
• Gene: Lamc1 Location: Chr1:153094668-153208532 bp, - strand Genetic Position: Chr1, 65.3 cM
• Alliance: Lamc1^tm1.1Strl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199683
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by single loxP sites. An frt flanked neomycin resistance cassette was inserted upstream of the floxed region, in intron 1. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. (J:199683)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamc1 Mutation: 143 strains or lines available

References

• Original: J:199683 McKee KK, et al., Schwann cell myelination requires integration of laminin activities. J Cell Sci. 2012 Oct 1;125(Pt 19):4609-19
• All: 4 reference(s)