Ctnna3^tm1.1Fvr
Targeted Allele Detail

Summary

• Symbol: Ctnna3^tm1.1Fvr
• Name: catenin alpha 3; targeted mutation 1.1, Frans van Roy
• MGI ID: MGI:5504493
• Synonyms: alphaT-catenin KO
• Gene: Ctnna3 Location: Chr10:63265877-64839446 bp, + strand Genetic Position: Chr10, 32.57 cM
• Alliance: Ctnna3^tm1.1Fvr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197814
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. A floxed neomycin resistance cassette was inserted downstream of exon 3. Cre-mediated recombination removed exon 3 and the neomycin resistance cassette. Western blot analysis confirmed the absence of protein expression in the heart. (J:197814)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ctnna3 Mutation: 45 strains or lines available

References

• Original: J:197814 Li J, et al., Loss of alphaT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia. J Cell Sci. 2012 Feb 15;125(Pt 4):1058-67
• All: 4 reference(s)