Pappa2^tm1.1Jkcs
Targeted Allele Detail

Summary

• Symbol: Pappa2^tm1.1Jkcs
• Name: pappalysin 2; targeted mutation 1.1, Julian K Christians
• MGI ID: MGI:5504500
• Gene: Pappa2 Location: Chr1:158539297-158788019 bp, - strand Genetic Position: Chr1, 68.49 cM
• Alliance: Pappa2^tm1.1Jkcs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199327
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neomycin resistance cassette. (J:199327)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pappa2 Mutation: 88 strains or lines available

References

• Original: J:199327 Christians JK, et al., Pregnancy associated plasma protein A2 (PAPP-A2) affects bone size and shape and contributes to natural variation in postnatal growth in mice. PLoS One. 2013;8(2):e56260
• All: 3 reference(s)