Pcdhg^tm1Sch
Targeted Allele Detail

Summary

• Symbol: Pcdhg^tm1Sch
• Name: protocadherin gamma cluster; targeted mutation 1, Martin K Schwarz
• MGI ID: MGI:5504501
• Synonyms: gamma-pcdh^neo
• Gene: Pcdhg Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98737
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed PGK-neo cassette was inserted 417 bp downstream of the gammaC1 exon and an additional loxP site was inserted 1026 bp upstream. mRNA production was severely impaired in heterozygotes. (J:98737)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcdhg Mutation: 13 strains or lines available

References

• Original: J:98737 Hambsch B, et al., {gamma}-Protocadherins, presenilin-mediated release of C-terminal fragment promotes locus expression. J Biol Chem. 2005 Apr 22;280(16):15888-97
• All: 2 reference(s)