Pcdhg^tm1.1Sch
Targeted Allele Detail

Summary

• Symbol: Pcdhg^tm1.1Sch
• Name: protocadherin gamma cluster; targeted mutation 1.1, Martin K Schwarz
• MGI ID: MGI:5504502
• Synonyms: gamma-pcdh^deltaC1
• Gene: Pcdhg Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98737
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed PGK-neo cassette was inserted 417 bp downstream of the gammaC1 exon and an additional loxP site was inserted 1026 bp upstream. The selection cassette and gammaC1 exon were removed by cre excision from properly targeted mice. In addition, this created a frame shift mutation. mRNA production was severely impaired in heterozygotes. (J:98737)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcdhg Mutation: 13 strains or lines available

References

• Original: J:98737 Hambsch B, et al., {gamma}-Protocadherins, presenilin-mediated release of C-terminal fragment promotes locus expression. J Biol Chem. 2005 Apr 22;280(16):15888-97
• All: 1 reference(s)