Shox2^{tm3.1(cre)Ypc}
Targeted Allele Detail

Summary

• Symbol: Shox2^{tm3.1(cre)Ypc}
• Name: SHOX homeobox 2; targeted mutation 3.1, YiPing Chen
• MGI ID: MGI:5504508
• Synonyms: Shox2^Cre
• Gene: Shox2 Location: Chr3:66879060-66889104 bp, - strand Genetic Position: Chr3, 30.76 cM, cytoband E3-F1
• Alliance: Shox2^{tm3.1(cre)Ypc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199319
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Shox2^{tm3.1(cre)Ypc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Shox2 (MGI:1201673)

• Mutation details: A targeting vector introduced the cre recombinase coding sequence and an frt-flanked PGK-neo selection cassette into the Shox2 locus via homologous recombination in ES cells, replacing exon 1, intron 1 and part of exon 2. Germline animals were crossed to Flp deleter mice to remove the PGK-neo cassette. (J:199319)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Shox2 (mouse) Summary of all recombinase alleles driven by Shox2. Alliance mouse Shox2 gene page

Expression

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shox2 Mutation: 20 strains or lines available

References

• Original: J:199319 Sun C, et al., Generation of Shox2-Cre allele for tissue specific manipulation of genes in the developing heart, palate, and limb. Genesis. 2013 Jul;51(7):515-22
• All: 11 reference(s)