About   Help   FAQ
P4hbtm1.1Geno
Targeted Allele Detail
Summary
Symbol: P4hbtm1.1Geno
Name: prolyl 4-hydroxylase, beta polypeptide; targeted mutation 1.1, Genoway
MGI ID: MGI:5504624
Synonyms: PDIflox
Gene: P4hb  Location: Chr11:120451124-120464079 bp, - strand  Genetic Position: Chr11, 84.27 cM, cytoband D-E
Alliance: P4hbtm1.1Geno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197556
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3'loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exons 1 and 2 floxed. (J:197556)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any P4hb Mutation:  32 strains or lines available
References
Original:  J:197556 Hahm E, et al., Extracellular protein disulfide isomerase regulates ligand-binding activity of alphaMbeta2 integrin and neutrophil recruitment during vascular inflammation. Blood. 2013 May 9;121(19):3789-800, S1-15
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory