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P4hbtm1.1Geno
Targeted Allele Detail
Summary
Symbol: P4hbtm1.1Geno
Name: prolyl 4-hydroxylase, beta polypeptide; targeted mutation 1.1, Genoway
MGI ID: MGI:5504624
Synonyms: PDIflox
Gene: P4hb  Location: Chr11:120451124-120464079 bp, - strand  Genetic Position: Chr11, 84.27 cM, cytoband D-E
Alliance: P4hbtm1.1Geno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:197556
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3'loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exons 1 and 2 floxed. (J:197556)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any P4hb Mutation:  32 strains or lines available
References
Original:  J:197556 Hahm E, et al., Extracellular protein disulfide isomerase regulates ligand-binding activity of alphaMbeta2 integrin and neutrophil recruitment during vascular inflammation. Blood. 2013 May 9;121(19):3789-800, S1-15
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory